The PHANTM classifier provides functional classification for any missense and nonsense variant using comprehensive experimental data. It currently supports functional classification for missense and nonsense variants in the gene TP53.
See paper link for details.

Enter Variant

Examples - Protein change : p.R273H or p.Arg273His,

Reference amino acid Arg
Protein change p.Arg273His
Combined phenotype score 1.221 ± 0.111
# of IARC somatic mutations (human tumors) 863
# of IARC germline mutations (LFL/LFS individuals) 92
# of ExAC germline mutations (unselected individuals) 3
Transcriptional activity in yeast (% of wild-type) 2.51%
Mutation probability (COSMIC Signature 1 percentile) 99.54%